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Each use contributes to a lasting 24-hour protection layer after every brush, so the work you do morning and evening keeps going long after you've put the toothbrush down. 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Brush teeth thoroughly for at least 1 minute twice a day (morning and evening), or as recommended by a dentist. Brush all sensitive areas thoroughly.\u003c\/li\u003e\n  \u003cli\u003e\n\u003cstrong\u003eKey Ingredients:\u003c\/strong\u003e Active: Stannous Fluoride 0.454%. 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